Bioinformatics Hub | John Brown | Activity https://bioinformaticshub.net/members/john/activity/ Activity feed for John Brown. Sun, 12 Apr 2026 14:14:29 +0000 https://buddypress.org/?v= en-US 30 hourly 2 5d6f8a22ea53e8221423ddb86448e0c2 John Brown posted an update: Top 10 Best-Selling Cell and Gene […] https://bioinformaticshub.net/activity/p/1628/ Sun, 23 Jun 2024 18:25:58 +0000 Top 10 Best-Selling Cell and Gene Therapies

Top 10 Best-Selling Cell and Gene Therapies

]]> 0 7307d0de35d30086e75c09ce2ff51618 John Brown replied to the topic What is the difference between gene knockout and gene knockdown? in the forum Discussion https://bioinformaticshub.net/forums/topic/what-is-the-difference-between-gene-knockout-and-gene-knockdown/#post-2907 Mon, 24 Apr 2023 07:37:44 +0000 Gene knockout is the total removal or permanent deactivation of a gene through inducing a targeted DNA damage. Knockout mice are commonly used in research to study the effects of genes that may have significance in human health.

Gene knockdown is the deactivation or suppression rather than deletion of the gene. Gene knockdown can be complete or…Read more

]]> 0 3a0c3bdcafaa093b0c1a9a0f7c9d535f John Brown replied to the topic Has gene editing or base editing succeeded in correcting a gene? in the forum Discussion https://bioinformaticshub.net/forums/topic/has-gene-editing-or-base-editing-succeeded-in-correcting-a-gene/#post-1769 Thu, 22 Sep 2022 05:57:48 +0000 The Huntington faulty gene has increased trinucleotide repeats that leads to formation of a faulty protein with a long polyglutamine tail. This abnormal protein misfolds, precipitates, and causes the known pathological changes in the affected person.

Current approaches targeting the gene aim at silencing this faulty gene to decrease the…Read more

]]> 0 dc949d803a3c71964732feaa38e3f82a John Brown replied to the topic What's the difference between a mosaic and a chimera? in the forum Discussion https://bioinformaticshub.net/forums/topic/whats-the-difference-between-a-mosaic-and-a-chimera/#post-1599 Thu, 08 Sep 2022 11:24:48 +0000 Both mosaic and a chimera have more than one cell line. While a chimeral results from fusion of two zygotes, a mosaic is monozygotic. A mosaic results from an early somatic mutation leading to a different cell line. It occurs in different species including humans.

Since cancer results from a mutation that gives the cell different genetic…Read more

]]> 0 3119dde0bdf030794630ffe61f54bb9e John Brown replied to the topic What is a chimeric person? in the forum Discussion https://bioinformaticshub.net/forums/topic/what-is-a-chimeric-person/#post-1509 Thu, 01 Sep 2022 14:40:08 +0000 Very rarely, a person can be dimeric with two different DNA fingerprints. In this person, a blood sample for example can have a DNA fingerprint different than that of a tissue sample. This can take place if one of two fraternal twin embryos dies and is absorbed by the other twin in utero.

In one episode of CSI, the rapist was acquitted based on a…Read more

]]> 0 23a632bd7fc59f2d934cec815bdc12b2 John Brown joined the group Medical https://bioinformaticshub.net/activity/p/818/ Sun, 28 Aug 2022 19:43:00 +0000 0 fea1c6e4acfa9f8806d33e261950803f John Brown posted a new activity comment https://bioinformaticshub.net/sma-gene-therapy/#comment-18 Thu, 30 Jun 2022 23:22:20 +0000 The high price is really a burden to any patient, in any country. It is the responsibility of insurance and health agencies to help patients with such rare diseases to get the required medication.
The high price is an established feature of orphan drugs, for orphan diseases. Enormous budgets are allocated to discovery of medications for rare…Read more

In reply to - Emil Luca wrote a new post SMA Gene Therapy Written by Emil Luca: Spinal muscular atrophy (SMA) is a rare neuromuscular disorder that results in the loss of motor neurons and progressive muscle […] ]]> 920157b95fb1fbe944c7ea5ebc69807b John Brown replied to the topic What is metabolome? in the forum Discussion https://bioinformaticshub.net/forums/topic/what-is-metabolome/#post-390 Fri, 11 Mar 2022 18:42:06 +0000 Metabolome is the total collection of metabolites present within an organism, a cell, or a tissue. Genome is the total collection of DNA in the cell of an organism. Similarly, the transcriptome is the total RNA and proteome is the total protein of a cell or tissue. While the genome is the same for all cells and tissues of an organism, the…Read more

]]> 0 184438733be10ba2b192a306927b665b John Brown posted an update: fine with me too. could be a temporary error? https://bioinformaticshub.net/activity/p/659/ Sat, 18 Dec 2021 05:07:50 +0000 fine with me too.
could be a temporary error?

]]> 0 b969f9f4796b19ef5af7c86a735d585a John Brown and Lena Hunt are now friends https://bioinformaticshub.net/activity/p/645/ Mon, 13 Dec 2021 11:58:07 +0000 0 17a8084eb8acef2960489e5614c0bb71 John Brown changed their profile picture https://bioinformaticshub.net/activity/p/641/ Sun, 12 Dec 2021 19:52:44 +0000 0 0cfce92a9084a4ef6a85a1b09f9de0af John Brown posted an update: Your confirmation letter takes too long to arrive. I found […] https://bioinformaticshub.net/activity/p/640/ Sun, 12 Dec 2021 19:44:10 +0000 Your confirmation letter takes too long to arrive.
I found it in the trash box.

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