Ribozymes and deoxyribozymes are two types of nucleic acid enzymes that can catalyze specific chemical reactions. Ribozymes are composed of RNA, while deoxyribozymes are composed of DNA. Some ribozymes are found in nature and play important roles in biological processes, such as RNA splicing and translation. Deoxyribozymes, on the other hand, are mostly artificial and have been discovered by in vitro selection from random sequences. Both ribozymes and deoxyribozymes have potential applications in biotechnology, such as biosensors and gene regulation. However, deoxyribozymes have some advantages over ribozymes, such as higher stability and easier binding to metal cofactors.