Metabolome is the total collection of metabolites present within an organism, a cell, or a tissue. Genome is the total collection of DNA in the cell of an organism. Similarly, the transcriptome is the total RNA and proteome is the total protein of a cell or tissue. While the genome is the same for all cells and tissues of an organism, the transcriptome, proteome, and metabolome are different from cell to cell or tissue to tissue. They are also different from one physiological state to another.