Does the corona virus replicase have a proof-reading activity?

[A. Hammouda]

Unlike DNA polymerase, RNA polymerase does not have a proofreading activity. This enzymatic activity ensures obtaining an exact replica of the nucleic acid that is copied. Lack of proofreading is a cause of the high rate of mutation of RNA viruses. COVOD-19 virus does not show the high rate of mutation like other RNA viruses, e.g., influenza virus. Is this because of proofreading activity of corona virus replicase?

[Fazil Hussein]

Do you mean the 3’→5′ exonuclease activity?

The answer is yes, sure.

This activity is also the cause why many nucleoside analogue antiviral drugs do not work with the corona virus.

 

[Author]

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