Activity Forums Discussion What is exclusome?

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    • #3273
      Mehreen A
      Participant

        What is exclusome?

        Is it the same as exosome?

      • #3278
        Fazil Hussein
        Moderator

          This is the answer generated by by Bard:

          Exclusome is a newly discovered organelle in mammalian cells. It is made up of DNA rings known as plasmids. It is located within the cell plasma. This discovery is significant because eukaryotic cells (cells with nuclei) usually keep most of their DNA in the cell nucleus, where it is organized into chromosomes. However, in the exclusome, the DNA is organized into plasmids – small, circular DNA strands that can replicate independently of chromosomes and are usually found in bacteria and other microscopic organisms.

          The function of the exclusome is still under investigation, but researchers believe it may play a role in gene expression and cell differentiation. It is also possible that the exclusome is involved in the immune response, as it has been found to contain proteins that are known to be involved in fighting infection.

          The discovery of the exclusome is a reminder that there is still much we don’t know about the inner workings of cells. It is also a testament to the power of scientific research, as it was only through careful observation and experimentation that scientists were able to identify this new organelle.

        • #3279
          A. Hammouda
          Keymaster

            The exclusome is a newly discovered cytoplasmic organelle in mammalian cells. The first publication about it was in September 2023 in Molecular Biology of the Cell:

            A dedicated cytoplasmic container collects extrachromosomal DNA away from the mammalian nucleus.

            Exclusome membrane is from endoplasmic reticulum and nuclear membrane. Circular DNA inside is foreign DNA and telomeric DNA from the nucleus.

            On the other hand, exosomes are membranous nanovesicles of endocytic origin released by most cell types from diverse organisms. Exosomes are present in many and perhaps all biological fluids, including blood, urine, and cultured medium of cell cultures.

            Exosome Databases

             

             

             

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