Activity Forums Discussion What is FENZOR? Is it something like CRISPR?

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    • #3987
      Robin
      Participant

        What is FENZOR?
        Is it something like CRISPR?

         

      • #3995
        Fazil Hussein
        Moderator

          FENZOR, also known as Fanzor, is indeed similar to CRISPR in that it is a genome-editing tool. However, it has some unique features that set it apart:

          1. Origin: Fanzor is the first RNA-guided DNA-cutting enzyme found in eukaryotes, whereas CRISPR systems were originally discovered in prokaryotes (bacteria and archaea).

          2. Mechanism: Like CRISPR, Fanzor uses RNA as a guide to target specific DNA sequences. This allows for precise genome editing.

          3. Size and Delivery: Fanzor proteins are more compact than CRISPR-Cas systems, which could make them easier to deliver into cells and tissues for therapeutic purposes.

          4. Potential: Researchers believe that with further refinement, Fanzor could become a valuable tool for human genome editing, potentially offering more precise and efficient editing capabilities compared to current CRISPR technologies.

          In summary, while Fanzor shares the fundamental principle of RNA-guided DNA editing with CRISPR, its discovery in eukaryotes and its compact size could provide new advantages in the field of genetic medicine.

           

        • #3996
          A. Hammouda
          Keymaster

            You may find this article useful:

            https://pubmed.ncbi.nlm.nih.gov/37380027/

             

          • #4001
            Dr. Kumar
            Participant

              Yes, FENZOR is similar to CRISPR. Both are gene editing tools that allow scientists to precisely modify DNA sequences.

              However, FENZOR has a unique advantage: it’s the first programmable RNA-guided system discovered in eukaryotes. This means it’s more likely to be compatible with human cells and other complex organisms.

              Key similarities to CRISPR:

              RNA-guided: Both systems use RNA molecules to target specific DNA sequences.
              Gene editing: Both can be used to insert, delete, or modify genes.

              Key difference:

              Origin: CRISPR originated from bacteria, while FENZOR was discovered in a higher organism.

              Overall, FENZOR is a promising new tool with potential applications in various fields, including medicine and biotechnology.

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