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  • Hamdy Ahmad
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      Protein C deficiency is a rare genetic trait that predisposes to thrombotic disease. It was first described in 1981. The disease belongs to a group of genetic disorders known as thrombophilias. Protein C deficiency is associated with an increased incidence of venous thromboembolism (relative risk 8–10), whereas no association with arterial thrombotic disease has been found.

      Here is a complete description:

      Protein C deficiency – Wikipedia

      in reply to: What is DNA replication-related template switching? #3530
      Hamdy Ahmad
      Participant

        DNA replication–related template switching is a mutation mechanism that creates reverse-complement copies of sequence regions within a genome by replicating briefly along either the complementary or nascent DNA strand.

         

        Hamdy Ahmad
        Participant

          According to Merriam-Webster dictionary,

          microbiome:

          1- a community of microorganisms (such as bacteria, fungi, and viruses) that inhabit a particular environment and especially the collection of microorganisms living in or on the human body.

          2- the collective genomes of microorganisms inhabiting a particular environment and especially the human body.

          microbiota:

          1- the microscopic organisms of a particular environment.

          2- MICROBIOME sense 1

           

           

          in reply to: What is DNA barcoding? #3241
          Hamdy Ahmad
          Participant

            DNA barcoding is a method of species identification using a short sequence of DNA from a specific gene or genes. Each species has a unique marker sequence like a product in a supermarket having a unique barcode.

            Source: DNA barcoding – Wikipedia

             

             

            in reply to: What is digital PCR? #3203
            Hamdy Ahmad
            Participant
              in reply to: What genes were modified in the donor pig? #280
              Hamdy Ahmad
              Participant

                A major genetic difference between humans/higher apes and pigs is that they do not share a working version of gal-transferase.

                That gene is called galactose-alpha-1,3,galactotransferase — gal-transferase for short . All mammals except humans and higher apes have a working version of gal-transferase, which coats cells with an antigen. This means if pig tissue is transplanted into humans our immune system will mount a drastic rejection response as our bodies detect the antigen and attack it. Pigs weren’t part of that lineage. This is a fact, established by comparative research on genomes. Humans are closely related to chimpanzees (and gorillas), with whom we share this missing gene.

                source: evolution – Are humans descended from chimp-pig hybrids? – Skeptics Stack Exchange

                in reply to: What is bioinformatics? #203
                Hamdy Ahmad
                Participant

                  Bioinformatics is all about computer aided biological research on a molecular level.

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