What is the difference between G-C and A-T pairings in DNA structure? - Bioinformatics Hub

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Tagged: base pairing, DNA

This topic has 2 replies, 3 voices, and was last updated 3 years, 4 months ago by W. Norman.

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- 2023-06-29 at 1:18 pm #3092
  Roy Flint
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  What is the difference between G-C and A-T pairings in terms of double helix formation in DNA structure?
- 2023-06-30 at 6:58 am #3093
  S. Khan
  Participant
  One difference is that G pairs to C with 3 hydrogen bonds, whereas A pairs to T with 2 hydrogen bonds. This makes G-C pairing stronger than A-T pairing, and G-C-rich DNA more difficult to denature. Both types of pairing are important for stabilizing the double helical structure. This pairing is also important for replication of DNA.
- 2023-07-01 at 9:00 am #3095
  W. Norman
  Participant
  Notice also that C at specific CpG sequences is the site of DNA methylation. This a type of epigenetic modification of the genome.
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